The Raab Lab

Chromatin regualators are among the most frequent mutations in hepatocellular carcinoma and cholangiocarcinoma. We are interested in how disruption of normal chromatin regulation gives rise to these tumors. We are also looking for new therapeutic strategies targeting the epignome. We use high throghgput CRISPR screens to uncover new therapeutic avenues.

How is composition and assembly of chromatin remodeling complexes regulated? Chromatin remodelers are large multi-subunit complexes that can be assembled in a variety of ways. We use genome-wide approaches to understand how these complexes find their targets in the genome, what they do when the get there, and how remodeling complex assembly is regulated. We are currently focusing on the role of post-translational modifications on non-histone proteins and RNA interactions as key mediators of complex assembly and function.