The Raab Lab

Chromatin regulators are among the most frequently mutated genes in hepatocellular carcinoma and cholangiocarcinoma. We are interested in how disruption of normal chromatin regulation drives the development of these tumors. We are also exploring new therapeutic strategies targeting the epigenome, using high-throughput CRISPR screens to uncover novel therapeutic avenues.

Chromatin remodelers are large, multi-subunit complexes that can be assembled in diverse configurations. We use genome-wide approaches to understand how these complexes locate their genomic targets, what they do once they arrive, and how their assembly is regulated. Our current focus is on the roles of post-translational modifications of non-histone proteins and RNA interactions as key mediators of complex assembly and function.